Rate uncertainty sinks stocks

The Federal Reserve's decision to hold interest rates steady left investors uncertain about future rate hikes. The markets extended its losses during the midday with the Dow collapsing 265 points to 16,409. Nasdaq plummeted 56 points to 4,837.

On the upside

Vascular Biogenics (Nasdaq: VBLT) will present Phase 2 data for its VB-111 in combination with Bevacizumab at the European Society for Medical Oncology's European Cancer Congress 2015 next week.

AbbVie (NYSE: ABBV) will open a new research facility in Cambridge.

Shares of Cablevision Systems (NYSE: CVC) rose again.

On the downside

Sientra (Nasdaq: SIEN) priced its follow-on public offering of 3 million common shares at the discounted price of $22 per share.

Shares of ImmunoGen (Nasdaq: IMGN) fell after hosting an analyst and investor event this morning.

Falling crude oil prices weighed down shares of Petrobras (NYSE: PBR).

In the broad market, declining issues outpaced advancers by a margin of nearly 2 to 1 on the NYSE and by more than 2 to 1 on Nasdaq. The broader S&P 500 plunged 24 points to 1,965. Bitcoin eased a fraction to $231.
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